Centre for Health Solutions – Kenya (CHS) is an indigenous, not-for-profit organisation that utilises local expertise and strategic partnerships to ensure the implementation of evidence informed solutions and interventions to address existing and emerging public health concerns.
CHS supports the Ministry of Health’s HIV response in HIV prevention, care and treatment. Introduction of new antiretroviral medicines as they become commercially available is a key component in HIV treatment optimization.
Monitoring adverse drug reactions related to new drugs is essential for patient safety. Following reports of adverse birth outcomes among pregnant women using dolutegravir at the time of conception in Botswana, MOH and its partners has been monitoring the situation in the 24 facilities and has developed a protocol to follow up pregnancy outcomes among women who were using peri-conception dolutegravir based regimen.
The objectives of this follow-up assessment is to:
- Compare the prevalence of Neuro Tube Defect (NTD)-affected pregnancies among women with periconceptional Dolutegravir (DTG) exposure to the prevalence of NTD-affected pregnancies among women with periconceptional EFV exposure
- Assess risk factors for NTDs among women with periconceptional DTG exposure compared to women with periconceptional EFV exposure
- Ascertain other adverse pregnancy outcomes after 20 weeks gestation
- Measure the frequency of adverse pregnancy outcomes among women exposed to DTG during pregnancy that fall outside of the periconceptional period
CHS is currently sourcing for a high calibre, self-motivated and dynamic individual to fill the position of National Study Coordinator.
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